بررسی ارتباط میزان بیان ژن پروتئین متصل شونده به عنصر تنظیمی استرول با پروفایل لیپیدی

Background and purpose: Atherosclerosis is a form of arteriosclerosis that is one of the main causes of death in the world.&nbsp; In coronary artery disease, the vessels are stenosed due to lipid aggregation and inflammation.&nbsp; Epidemiologic studies have shown that in addition to demographic factors such as age and sex, blood pressure, smoking, obesity diabetes and genetics are also associated with development of atherosclerosis process. The aim of this study was to examine the relationship between these factors and atherosclerosis. Materials and methods: One hundred twenty six Iranian subjects (68 males, 58 females) were recruited based on the study&rsquo;s inclusion criteria. Total RNA was extracted from WBC and, the gene expression level was determined by RT-qPCR method. Results: Significant relationship was found between sex (P<0.018) and LDL-C (P<0.05) with Sterol regulatory element-binding protein-2 gene expression. No correlation was observed between HDL-C, total cholesterol, and age with Sterol regulatory element-binding protein-2 gene expression (P>0.05). Conclusion: We found that among factors affecting atherosclerosis, sex and LDL-C could change the Sterol Regulatory Element-Binding Protein-2 gene expression.